Dendritic Cell Nibbling from Live Cells A Role for Class A Scavenger Receptor in and Simon M. Barratt-Boyes

A role for class A scavenger receptor in dendritic cell nibbling from live cells.

Monocyte-derived dendritic cells (DC) possess the unique capacity to capture Ag from live cells through intimate cell contact, a process referred to as nibbling. We sought to define the receptor(s) mediating DC nibbling. Uptake of fluorescently labeled plasma membrane from live cells by DC was inhibited by protease treatment and by a panel of polyanionic ligands, implicating scavenger receptors...

Cell-Based Vaccines Monkeys: Implications for Dendritic Monocyte-Derived Dendritic Cells in Maturation and Trafficking of

Tissue in Simian AIDS Dendritic Cells from Blood and Lymphoid Parallel Loss of Myeloid and Plasmacytoid

Dendritic cells acquire antigens from live cells for cross-presentation to CTL.

Dendritic cells (DC) can readily capture Ag from dead and dying cells for presentation to MHC class I-restricted CTL. We now show by using a primate model that DC also acquire Ag from healthy cells, including other DC. Coculture assays showed that fluorescently labeled plasma membrane was rapidly and efficiently transferred between DC, and transfer of intracellular proteins was observed to a le...

القای سلول‌های دندریتیک تولروژن موشی با تنظیم کاهشی ملکول کمک تحریکی CD40 با استفاده از وکتور لنتی ویروس

Induction of Tolerogenic Murine Dendritic Cells by Downregulating the Co-stimulatory Molecule of CD40 Using Lentivirus Vector Mahmoodzadeh A1, Pourfatollah AA1, Karimi MH2, Moazzeni SM1 1Dept. of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2Transplantation Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Correspond Aut...